Autophagy. Volume 3, Mitophagy cancer, other pathologies, inflammation, immunity, infection and aging için kapak resmi
Başlık:
Autophagy. Volume 3, Mitophagy cancer, other pathologies, inflammation, immunity, infection and aging
Dil:
English
ISBN:
9780124055346
Yayın Bilgileri:
Burlington : Elsevier Science, 2014.
Fiziksel Tanımlama:
1 online resource (432 pages)
İçerik:
1. Introduction to autophagy: Cancer, other pathologies, inflammation, immunity, infection and aging -- 2. Autophagic flux, fusion dynamics, and cell death -- 3. Architecture of the Atg12 -- Atg5 -- Atg16 complex and its molecular role in autophagy -- 4. The molecular mechanisms underlying autophagosome fomration in yeast -- 5. Role of autophagy in cell survival in liver injury -- 6. Polymorphisms in autophagy-related genes in Crohn's disease: Impact on intracellular bacteria persistence and inflammatory ... 7. Functional relevance of autophagins in life and disease -- 8. Strategies to block autophagy in tumor cells -- 9. Autophagic dysfunction in Guacher disease and its rescue by cathepsin B and D proteases -- 10. Cargo recognition failture underlies macroautophagy defects in Huntington's disease -- 11. Hepatitis C virus infection, autophagy, and innate immune response -- 12. Geranylgeranoic acid induces incomplete autophagy but leads to the accumulation of autophagosomes in human hepatoma cell ... 13. Defense against proteotoxic stress in the heart: Role of p62, autophagy, and ubiquitin-proteasome system -- 14. Elimination of intracellular bacteria by autophagy -- 15. Protein phosphatase 2A has positive and negative roles in autophagy -- 16. Erufosine induces autophagy and apoptosis in oral squamous cell carcinoma: Role of the Akt-mTOR signaling pathway -- 17. Emerging rle of hypoxia-induced autophagy in cancer immunotherapy -- 18. Involvement of autophagy and apoptosis in studies of anticancer drugs -- 19. Autophagy-based protein biomarkers for in vivo detection of cardiotoxicity ihn the context of cancer therapy -- 20. Inhibition of mTOR pathway and induction of autophagy block lymphoma cell growth: Role of AMPK activation -- 21. Autophagy regulates osteoarthritis-like gene expression change: Role of apoptosis and reactive oxygen species -- 22. The key role of autophagy and its relationship with apoptosis in lepidopteran larval midgut remodeling -- 23. Interferon regulatory factor 1 regulates both autophagy and apoptosis in splenocytes during sepsis -- 24. The interplay between autophagy and apoptosis.
Özet:
Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst encouraging researchers to explore their potentially important connections. Volume 3 explores the role of autophagy in specific diseases and developments, including: Crohn's Disease, Gaucher Disease, Huntington's Disease, HCV infection, osteoarthritis, and liver injury. A full section is devoted to in-depth exploration of autophagy in tumor development and cancer. Finally, the work explores the relationship between autophagy and apoptosis, with attention to the ways in which autophagy regulates apoptosis, and the ways in which autophagy has been explored in Lepidoptera, elucidating the use of larval midgut as a model for such exploration. From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases.

Mevcut:*

Materyal Türü
Demirbaş Numarası
Yer Numarası
Raf Konumu
Mevcut Konumu
Materyal Istek
E-Kitap 1344207-1001 QP601 .A384 2014 Elsevier E-Kitap Koleksiyonu
Arıyor...

On Order

Özet

Özet

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst encouraging researchers to explore their potentially important connections.

Volume 3 explores the role of autophagy in specific diseases and developments, including: Crohn's Disease, Gaucher Disease, Huntington's Disease, HCV infection, osteoarthritis, and liver injury. A full section is devoted to in-depth exploration of autophagy in tumor development and cancer. Finally, the work explores the relationship between autophagy and apoptosis, with attention to the ways in which autophagy regulates apoptosis, and the ways in which autophagy has been explored in Lepidoptera, elucidating the use of larval midgut as a model for such exploration. From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases.

Volumes in the Series