New Concepts of Antiviral Therapy için kapak resmi
Başlık:
New Concepts of Antiviral Therapy
Dil:
English
ISBN:
9780387310473
Yayın Bilgileri:
Boston, MA : Springer US, 2006.
Fiziksel Tanımlama:
XX, 538 p. online resource.
İçerik:
Concepts of therapy for RNA viruses -- Therapeutic vaccination in chronic hepadnavirus infection -- Characterization of targets for antiviral therapy of Flaviviridae infections -- Inhibition of Hepatitis C virus by nucleic acid-based antiviral approaches -- Inhibitors of respiratory viruses -- Anti-viral approaches against influenza viruses -- A new approach to an Influenza virus live vaccine: Modification of eleavage site of the haemagglu reverse genetics -- New concepts in anti-HIV therapies -- Evaluation of current strategies to inhibit HIV entry, integration and maturation -- Managing antiretroviral resistance -- Concepts of therapy for DNA viruses -- Selective inhibitors of the replication of poxviruses -- Maribavir: A promising new antiherpes therapeutic agent -- Benzimidazole-D-ribonucleosides as antiviral agents that target HCMV terminase -- Recent developments in anti-herpesviral therapy based on protein kinase inhibitors -- Immune therapy against papillomavirus-related tumors in humans -- Concepts of therapy for emerging viruses -- The SARS Coronavirus receptor ACE 2 A potential target for antiviral therapy -- Therapy of Ebola and Marburg virus infections -- General concepts of therapy -- Proteasome inhibitors as complementary or alternative antiviral therapeutics -- Human monoclonal antibodies for prophylaxis and therapy of viral infections -- Vector-based antiviral therapy.
Özet:
Antiviral drugs are important tools for treatment or prevention of viral infections. These drugs were first used for monotherapy, but nowadays combinations of antiviral agents are often part of a standard treatment as evidenced by e.g. HAART (highly active antiretroviral therapy). However, in almost every case of antiviral therapy, drug resistant viruses appear. In addition, the low oral bioavailability, toxicity and the number of severe side effects still pose significant problems. All of the latter issues limit the clinical usefulness and drive the need for improved antiviral strategies. These strategies include new drugs and targets, novel modes of action, vector-based treatments and even the block of defined genes by inhibiting mRNA formation (siRNA). Highlights of this book include the discussion of: - novel, promising compounds - concepts of therapy for new/emerging viruses - managing drug resistance - new therapeutic strategies This book presents an overview of the most recent developments. Contributions were carefully selected to ensure quality coverage by acknowledged experts over a wide spectrum and should prove to be of great value to students and serve as a compendium for R and D and educational professionals.

Mevcut:*

Materyal Türü
Demirbaş Numarası
Yer Numarası
Raf Konumu
Mevcut Konumu
Materyal Istek
E-Kitap 1815701-1001 QR355 -502 SPRINGER E-Kitap Koleksiyonu
Arıyor...

On Order

Özet

Özet

Antiviral drugs are vital - but imperfect - tools for treatment and prevention of viral infections. Undesirable effects, from drug resistant viruses to low oral bioavailability, toxicity and severe side effects limit clinical usefulness. These factors drive demand for improved antiviral strategies. This book offers an up-to-date review of new drugs and targets, novel modes of action, vector-based treatments and even the blocking of defined genes by inhibiting mRNA formation (siRNA). Includes contributions by acknowledged experts; the book will serve as a compendium for R&D and educational professionals, and be of value for students.


İçindekiler

Michael Roggendorf and Mengji LuPeter BorowskiMichael Frese and Ralf BartenschlagerErnst Kuechler and Joachim SeipeltStephen Pleschka and Stephan Ludwig and Thorsten Wolff and Oliver PlanzJürgen Stech and Holger Garn and Hans-Dieter KlenkJustin Stebbing and Mark Bower and Brian GazzardJaqueline D. Reeves and Stephen D. Barr and Stephan PöhlmannBarbara Schmidt and Monika Tschoschner and Hauke Walter and Klaus KornJohn Neyts and Erik de ClercqKaren K. BironJohn C. Drach and Leroy B. Townsend and Elke BognerThomas Herget and Manfred MarschallLutz GissmannJens H. Kuhn and Sheli R. Radoshitzky and Wenhui Li and Swee Kee Wong and Hyeryun Choe and Michael FarzanMike BraySusanna Prösch and Marion KaspariJan ter Meulen and Jaap GoudsmitArmin Ensser
Contributorsp. xi
Prefacep. xvii
Acknowledgmentsp. xix
Part 1 Concepts of therapy for RNA viruses
1.1 Therapeutic vaccination in chronic hepadnavirus infectionp. 3
1.2 Characterization of targets for antiviral therapy of Flaviviridae infectionsp. 21
1.3 Inhibition of Hepatitis C virus by nucleic acid-based antiviral approachesp. 47
1.4 Inhibitors of respiratory virusesp. 87
1.5 Anti-viral approaches against influenza virusesp. 115
1.6 A new approach to an Influenza virus live vaccine: Modification of cleavage site of the haemagglutinin by reverse geneticsp. 169
1.7 New concepts in anti-HIV therapiesp. 189
1.8 Evaluation of current strategies to inhibit HIV entry, integration and maturationp. 213
1.9 Managing antiretroviral resistancep. 255
Part 2 Concepts of therapy for DNA viruses
2.1 Selective inhibitors of the replication of poxvirusesp. 283
2.2 Maribavir: A promising new antiherpes therapeutic agentp. 309
2.3 Benzimidazole-D-ribonucleosides as antiviral agents that target HCMV terminasep. 337
2.4 Recent developments in anti-herpesviral therapy based on protein kinase inhibitorsp. 351
2.5 Immune therapy against papillomavirus-related tumors in humansp. 373
Part 3 Concepts of therapy for emerging viruses
3.1 The SARS Coronavirus receptor ACE 2 A potential target for antiviral therapyp. 397
3.2 Therapy of Ebola and Marburg virus infectionsp. 419
Part 4 General concepts of therapy
4.1 Proteasome inhibitors as complementary or alternative antiviral therapeuticsp. 455
4.2 Human monoclonal antibodies for prophylaxis and therapy of viral infectionsp. 479
4.3 Vector-based antiviral therapyp. 507
Indexp. 533