Immune Mechanisms in Inflammatory Bowel Disease için kapak resmi
Başlık:
Immune Mechanisms in Inflammatory Bowel Disease
Dil:
English
ISBN:
9780387337784
Yayın Bilgileri:
New York, NY : Springer New York : Imprint: Springer, 2006.
Fiziksel Tanımlama:
XVI, 248 p. 34 illus., 2 illus. in color. online resource.
Seri:
Advances in Experimental Medicine and Biology, 579
İçerik:
Structure and Function of the Gut Mucosal Immune System -- Functional Aspects of the Mucosal Immune System -- Recent Progress in Inflammatory Bowel Disease Genetics -- Microbial and Dietary Factors in the Pathogenesis of Chronic, Immune-Mediated Intestinal Inflammation -- Experimental Models of Mucosal Inflammation -- Overview of Role of the Immune System in the Pathogenesis of Inflammatory Bowel Disease -- The Role of the Epithelial Barrier in Inflammatory Bowel Disease -- Involvement of Dendritic Cells in the Pathogenesis of Inflammatory Bowel Disease -- Alterations of T Lymphocytes in Inflammatory Bowel Diseases -- The B-Cell System in Inflammatory Bowel Disease -- Alterations of Mesenchymal and Endothelial Cells in Inflammatory Bowel Diseases -- Role of Mast Cells and Eosinophils in Neuroimmune Interactions Regulating Mucosal Inflammation in Inflammatory Bowel Disease -- Multiparameter Analysis of Immunogenetic Mechanisms in Clinical Diagnosis and Management of Inflammatory Bowel Disease -- The Role of Probiotics and Antibiotics in Regulating Mucosal Inflammation -- From Immunogenic Mechanisms to Novel Therapeutic Approaches in Inflammatory Bowel Disease.
Özet:
Immune Mechanisms in Inflammatory Bowel Disease is a highly, concise update of the most recent advances in the immunobiology, genetics and microbiology related to Inflammatory Bowel Disease. This book broadly treats the topics that lead to understanding of the pathogenesis of this disease in an organized, systematic approach.

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Özet

Immune Mechanisms in Inflammatory Bowel Disease is a highly, concise update of the most recent advances in the immunobiology, genetics and microbiology related to Inflammatory Bowel Disease. This book broadly treats the topics that lead to understanding of the pathogenesis of this disease in an organized, systematic approach.


İçindekiler

Reinhard Pabst and Hermann J. RothkotterCathryn Nagler-AndersonJudy H. ChoR. Balfour SartorWarren Strober and Ivan J. FussThomas T. MacDonald and Giovanni MonteleoneEdward E.S. Nieuwenhuis and Richard S. BlumbergFrancisco Leon and Lesley E. Smythies and Phillip D. Smith and Brian L. KelsallCharles O. Elson and Yingzi Cong and Casey T. WeaverPer Brandtzaeg and Hege S. Carlsen and Trond S. HalstensenClaudio Fiocchi and Kenji Ina and Silvio Danese and Andre Z.A. Leite and Jon D. VogelStephan C. Bischoff and Thomas GebhardtJonathan Braun and Stephan R. TarganRainer DuchmannMartin H. Holtmann and Markus F. Neurath
1 Structure and Function of the Gut Mucosal Immune Systemp. 1
Introductionp. 1
Intraepithelial Lymphocytes (IEL)p. 1
Lamina Propria Lymphocytes (LPL)p. 3
Lymphocyte-Filled Villi (LFV)p. 4
Cryptopatches (CP)p. 5
Isolated Lymphoid Follicles (DLF)p. 5
Peyer's Patches (PP)p. 6
Lymphoid Structures in the Large Intestinep. 7
Mesenteric Lymph Nodes, Part of the Gut Immune Systemp. 7
Gut Lymphaticsp. 8
Liver-Also a Part of the Gut Immune System?p. 8
Dynamics in the Gut Immune Systemp. 9
Conclusionsp. 9
Note Added in Proofp. 9
2 Functional Aspects of the Mucosal Immune Systemp. 15
Phenotypically and Functionally Unique Lymphocyte Populations in the Gut Associated Lymphoid Tissuep. 15
Mechanisms Governing Non-Responsiveness to Food Proteins and Commensal Bacteriap. 18
3 Recent Progress in Inflammatory Bowel Disease Geneticsp. 24
Introductionp. 24
IBD Epidemiologyp. 24
The Human Genome Project and the Challenge of Complex Genetic Disordersp. 25
Linkage Studies in IBDp. 26
Association Studies in IBDp. 27
Future Directionsp. 30
4 Microbial and Dietary Factors in the Pathogenesis of Chronic, Immune-Mediated Intestinal Inflammationp. 35
Introductionp. 35
Evidence of Bacterial Induction and Maintenance of Intestinal Inflammationp. 38
Induction of Mucosal Immune Responses by Bacterial and Dietary Antigens and Adjuvantsp. 42
Conclusionp. 48
5 Experimental Models of Mucosal Inflammationp. 55
Introductionp. 55
General Features of Models of Mucosal Inflammationp. 56
Representative Models of Mucosal Inflammationp. 68
Tabular Summary of Models of Mucosal Inflammationp. 80
Conclusionp. 80
6 Overview of Role of the Immune System in the Pathogenesis of Inflammatory Bowel Diseasep. 98
Abstractp. 98
Introductionp. 98
Crohn's Disease, but Not Ulcerative Colitis Bears the Stigmata of a Th1 Mediated Immune Responsep. 99
The Role of T Cells in Ulcerative Colitisp. 100
The Role of Antibody in Ulcerative Colitisp. 100
Nonspecific Effector Mechanisms Down-Stream of the Immune System Cause Tissue Injury in Crohn's Disease and Ulcerative Colitisp. 102
The Immune System Fails to Negatively Regulate in CD and UCp. 103
7 The Role of the Epithelial Barrier in Inflammatory Bowel Diseasep. 108
Introductionp. 108
Bacteria and the Epitheliump. 108
Bacteria and IBDp. 109
The Epithelial Cell as Effector Cell in IBDp. 110
Luminal Antigens, Fate and Processingp. 112
IEC and Mucosal Barrier Function/Permeabilityp. 113
Conclusionp. 113
8 Involvement of Dendritic Cells in the Pathogenesis of Inflammatory Bowel Diseasep. 117
Introductionp. 117
Current Views on Dendritic Cell Biologyp. 117
Intestinal Dendritic Cellsp. 119
Dendritic Cells in Inflammatory Bowel Diseasep. 122
Intestinal Macrophagesp. 126
Intestinal Macrophages in IBDp. 126
Summaryp. 127
9 Alterations of T Lymphocytes in Inflammatory Bowel Diseasesp. 133
CD4[superscript +] T Cell Subsets in the Intestinep. 134
Intestinal T Effector Cellsp. 136
Th2 Effectors in IBDp. 136
Intestinal T Regulatory Cellsp. 138
CD4[superscript +]CD45RB[superscript Io] T Cellsp. 138
T-Regulatory-1 Cells (Tr1)p. 139
T-Helper-3 Cells (Th3)p. 139
[alpha subscript E Beta subscript 7 superscript +] T Cellsp. 140
What Drives Effector and Regulatory T Cells in IBD?p. 141
Conclusionp. 143
10 The B-Cell System in Inflammatory Bowel Diseasep. 149
Abstractp. 149
Introductionp. 150
B Cell-Mediated Mucosal Homeostasis in the Normal Gutp. 150
Humoral Immunity and Immune Exclusion in IBD Lesionsp. 152
Local Production of Antibodies to the Indigenous Gut Flora in IBDp. 153
Local Production of Anti-Epithelial IgG1 Autoantibodies in Ulcerative Colitisp. 154
Local Production and Diagnostic Aid of Other (Auto)Antibodies in IBDp. 156
Mechanisms for Induction of Local Proinflammatory B-Cell Responsesp. 157
IBD Apparently Reflects Break of Oral Tolerance against Indigenous Bacteriap. 161
11 Alterations of Mesenchymal and Endothelial Cells in Inflammatory Bowel Diseasesp. 168
Abstractp. 168
Introductionp. 168
Mesenchymal Cellsp. 169
Smooth Muscle Cellsp. 169
Fibroblasts and Myofibroblastsp. 169
Endothelial Cellsp. 170
Human Intestinal Microvascular Endothelial Cellsp. 171
Integration of Intestinal Immune-Nonimmune Cell Interactions by the CD40/CD40 Ligand Systemp. 172
12 Role of Mast Cells and Eosinophils in Neuroimmune Interactions Regulating Mucosal Inflammation in Inflammatory Bowel Diseasep. 177
Introductionp. 177
Intestinal Mast Cells and Eosinophilsp. 178
Role of Mast Cells and Eosinophils in Intestinal Inflammationp. 182
Structure and Function of The Enteric Nervous Systemp. 184
Mechansims of Mast Cell / Eosinophil-Neuroimmune-Crosstalk in the Gutp. 186
Neurophysiological Effects of Mast Cell and Eosinophil Activationp. 191
Alterations of Neuroimmune-Crosstalk in IBDp. 194
Conclusionsp. 197
13 Multiparameter Analysis of Immunogenetic Mechanisms in Clinical Diagnosis and Management of Inflammatory Bowel Diseasep. 209
Abstractp. 209
NOD2 and Innate Anti-Microbial Processes in IBD Diagnosisp. 209
Anti-Microbial Antibodies and Adaptive Immune Components in IBD Diagnosisp. 211
Autoantibodies in IBD Diagnosisp. 213
Multiparameter Analysis of Immunogenetic Traits in IBD Diagnosisp. 213
14 The Role of Probiotics and Antibiotics in Regulating Mucosal Inflammationp. 219
Abstractp. 219
Probiotics: Animal Studies and Clinical Trialsp. 219
Probiotics: Mechanismsp. 220
Antibiotics: Animal Studies and Clinical Trialsp. 221
Antibiotics: Mechanismsp. 221
General Problemsp. 222
Perspectivesp. 222
15 From Immunogenic Mechanisms to Novel Therapeutic Approaches in Inflammatory Bowel Diseasep. 227
Abstractp. 227
Introductionp. 227
Genetic Factorsp. 228
Physiological "Hyporeactivity" of the Intestinal Immune Systemp. 229
Activation of the Mucosal Immune System in IBDp. 229
Novel Therapeutic Approachesp. 234
Concluding Remarksp. 238
Indexp. 243